Clinicopathological Study of Lymphatic Vessel Density and Distribution
in Pancreatic Cancer

Jin Gang, Hu Xian-gui, Liu Rui, Zhang Yi-jie, Shao Cheng-hao, Tang Yan

Acta Academiae Medicinae Sinicae ›› 2005, Vol. 27 ›› Issue (5) : 583-586.

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Acta Academiae Medicinae Sinicae ›› 2005, Vol. 27 ›› Issue (5) : 583-586.
Original Articles

Clinicopathological Study of Lymphatic Vessel Density and Distribution
in Pancreatic Cancer

  • Jin Gang, Hu Xian-gui, Liu Rui, Zhang Yi-jie, Shao Cheng-hao, Tang Yan
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Abstract

Abstract: Objective To clarify the clinicopatological significance of lymphatic vessel density (LVD)and distribution in pancreatic cancer. Methods We measured LVD in 43 pancreatic cancer specimens by immunostaining with specific lymphatic endothelium marker, and examined their relationship with well-defined clinicopathological variables. Results Intratumoral LVD(9.4 ± 10.0)was significantly lower than periturmoral(16.0 ± 9.7)(P < 0.001)and nontumoral LVD(13.5 ± 6.0)(P < 0.01). Increased peritumoral LVD correlated significantly with tumor staging(P < 0.05)and lymph node involvement(P < 0.05). Conclusion The lymphatic vessels distribution in pancreatic cancer samples and peritumoral lym- phangiogenesis may promote the malignant progression and lymph node metastasis of pancreatic cancer.

Key words

pancreatic ductal carcinomas / lympdatic vessel / metastasis

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Jin Gang, Hu Xian-gui, Liu Rui, Zhang Yi-jie, Shao Cheng-hao, Tang Yan. Clinicopathological Study of Lymphatic Vessel Density and Distribution
in Pancreatic Cancer
. Acta Academiae Medicinae Sinicae. 2005, 27(5): 583-586

References

1 Kayahara M, Nagakawa T, Kobayashi H, et al. Lymphatic flow in carcinoma of the head of the pancreas. Cancer, 1992, 70(8):2061-2066

2 Hosch SB, Knoefel WT, Metz S, et al. Early lymphatic tumor cell dissemination in pancreatic cancer: frequency and prognostic significance. Pancreas, 1997, 15(2):154-159
3 Yeo CJ, Cameron JL, Lillemoe KD, et al. Pancreati- coduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluat- ing survival, morbidity, and mortality. Ann Surg, 2002, 236(3):355-366
4 Matsuno S, Egawa S, Fukuyama S, et al. Pancreatic cancer registry in Japan: 20 years of experience. Pancreas, 2004, 28(3):219-230
5 Bogoevski D, Yekebas EF, Schurr P, et al. Mode of spread in the early phase of lymphatic metastasis in panc- reatic ductal adenocarcinoma: prognostic significance of no- dal microinvolvement. Ann Surg, 2004, 240(6):993-1000
6 Sleeman JP, Krishnan J, Kirkin V, et al. Markers for the lymphatic endothelium: in search of the holy grail?芽 Microsc Res Tech, 2001, 55(2):61-69
7 Banerji S, Ni J, Wang SX, et al. LYVE-1, a new ho- mologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J Cell Biol, 1999, 22(4):789-801
8 Breiteneder-Geleff S, Soleiman A, Kowalski H, et al. An- giosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium. Am J Pathol, 1999, 154(2):385-
9 394
10 Wigle JT, Oliver G. Prox1 function is required for the development of the murine lymphatic system. Cell, 1999, 98(6):769-778
11 Kahn HJ, Marks A. A new monoclonal antibody, D2-40, for detection of lymphatic invasion in primary tumors. Lab Invest, 2002, 82(9):1255-1257
12 Japan Pancreas Society. Classification of pancreatic carci- noma. 2nd ed. Tokyo: Kanehara & Co., 2003.11-20
13 Trojan L, Michel MS, Rensch F, et al. Lymph and blood vessel architecture in benign and malignant prostatic tissue: lack of lymphangiogenesis in prostate carcinoma assessed with novel lymphatic marker lymphatic vessel endothelial hyaluronan receptor(LYVE-1). J Urol, 2004, 172(1):103-107
14 Yeo CJ, Cameron JL, Sohn TA, et al. Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: patho- logy, complications, and outcomes. Ann Surg, 1997, 226(3):248-257
15 Uomo G. Some more news on the metastatic pathway in pancreatic cancer. JOP, 2005, 6(1):42-46
16 Kahn HJ, Bailey D, Marks A. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Ka- posi’s sarcoma and a subset of angiosarcomas. Mod Pathol, 2002, 15(4):434-440
17 Franchi A, Gallo O, Massi D, et al. Tumor lymphan- giogenesis in head and neck squamous cell carcinoma: a morphometric study with clinical correlations. Cancer, 2004, 101(5):973-978
18 Choi WW, Lewis MM, Lawson D, et al. Angiogenic and lymphangiogenic microvessel density in breast carcinoma: correlation with clinicopathologic parameters and VEGF- family gene expression. Mod Pathol, 2005, 18(1):143-152
19 He Y, Kozaki K, Karpanen T, et al. Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. J Natl Cancer Inst, 2002, 94(11):819-825
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