摘要：目的 通过系统比较15种降压药单药治疗原发性高血压的降压疗效, 为医师选择有效降压药物时提供依据。方法 对370例原发性高血压患者应用动态血压监测对15种单药治疗8周的降压疗效进行系统比较。结果 氯沙坦、缬沙坦、厄贝沙坦、奥美沙坦、苯那普利、依那普利、美托洛尔、贝凡洛尔、吲达帕胺、贝尼地平和氨氯地平均有效降低24h平均舒张压和收缩压, 坎地沙坦能有效降低收缩压。但各单药间降压幅度无差异。而低剂量特拉唑嗪、多沙唑嗪仅能降低日间舒张压, 托拉塞米降低24h平均血压的效果不明显。结论 血管紧张素转换酶抑制剂、血管紧张素Ⅱ受体拮抗剂、β-阻滞剂和长效钙拮抗剂单药治疗能有效降压, 而单用低剂量特拉唑嗪、多沙唑嗪和托拉塞米因短期作用有限, 不建议作为单独药物治疗高血压, 作为联合治疗可能更为适宜。
Abstract
ABSTRACT:Objective To evaluate the efficacy of the monotherapy of 15 agents in treating essential hypertension. Methods After 2-week wash-out, a total of 370 patients with seated diastolic blood pressure 95- 114 mmHg and seated systolic blood pressure <180 mmHg were randomized to different therapeutic groups. 24-hour ambulatory blood pressure monitoring was performed before medication and at the end of 8 weeks. Result All the agents significantly reduced the 24 hour mean blood pressures after treatment except doxazosin, terazosin, and torasemide. Conclusion The result suggested that the angiotensin-converting enzyme inhibitors, angiotensin Ⅱreceptor blockers, β-blockers and long-acting calcium antagonists were effective in treating essential hypertension, while the low-dose doxazosin, terazosin and torasemide can be used for combination therapy but not for monotherapy.
关键词
原发性高血压 /
单药治疗 /
动态血压监测
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Key words
essential dypertension /
monotderapy /
ambulatory blood pressure monitorinc
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参考文献
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